How to Test for Sjögren’s Syndrome

Introduction: Why Testing for Sjögren’s Syndrome Requires a Deeper Approach

Sjögren’s Syndrome is more than just dry eyes and mouth—it’s an autoimmune condition that can affect multiple organs and go undiagnosed for years. At Patients Medical in NYC, we don’t just look at symptoms—we uncover the full story.

Using functional medicine, we investigate immune dysfunction, inflammation, hormone imbalances, and gut health to detect Sjögren’s at its core—often even before traditional labs confirm it.

What Is Sjögren’s Syndrome?

Sjögren’s Syndrome is an autoimmune condition where the body attacks its own moisture-producing glands, especially in the eyes and mouth. It may occur on its own (primary Sjögren’s) or alongside other autoimmune diseases like lupus, rheumatoid arthritis, or Hashimoto’s (secondary Sjögren’s).

Common Symptoms:
  • Dry eyes (gritty, burning sensation)
  • Dry mouth and difficulty swallowing
  • Fatigue and joint pain
  • Swollen salivary glands
  • Vaginal dryness
  • Brain fog and memory issues
  • Peripheral neuropathy
  • Chronic cough or dry sinuses

Many patients go undiagnosed for years because symptoms are vague or mistaken for aging, stress, or menopause.

 

Why Is Early Testing Important?

Sjögren’s can silently affect the lungs, kidneys, thyroid, and nervous system if left untreated. Early testing allows for:

Root Causes We Explore

Functional medicine asks why the immune system becomes confused. Often, the root drivers of Sjögren’s include:

  • Leaky gut and microbiome dysbiosis
  • Viral triggers (Epstein-Barr, CMV)
  • Hormonal imbalances (especially in perimenopause/postmenopause)
  • Toxic burden (heavy metals, mold, pesticides)
  • Chronic stress and adrenal fatigue
  • Undiagnosed thyroid dysfunction
  • Nutrient deficiencies impairing immune balance

Advanced Sjögren’s Diagnostics

We use cutting-edge testing:

Early Sjögren’s Panel (anti-SSA/Ro, anti-SSB/La)

Inflammatory Markers (ESR, CRP, cytokines)

Gut Health Analysis (zonulin, microbiome testing)

Environmental Toxin Screening (mycotoxins, heavy metals)

Vitamin/Mineral Testing (B12, D, selenium)

Salivary Gland Ultrasound (assesses gland damage)

Integrative Sjögren’s Treatments

Mucosal Restoration Therapies

  • Autologous serum eye drops (from patient’s blood)
  • Pro-biotic oral rinses (for oral microbiome balance)
  • Hyaluronic acid supplements (for moisture retention)

Immune Modulation

  • Low-dose naltrexone (LDN) (reduces inflammation)
  • IVIG therapy (for severe cases)
  • Peptide therapy (Thymosin alpha-1)

Gut-Immune Repair

  • Leaky gut protocols (glutamine, zinc carnosine)
  • Microbiome restoration (specific probiotic strains)
  • Autoimmune diet plans (AIP protocol)

Advanced Dryness Solutions

  • Lipiflow for meibomian glands
  • Electrostimulation for saliva production
  • Cevimeline alternatives (herbal secretagogues)

Systemic Support

  • IV hydration + nutrient therapy
  • Mitochondrial support (CoQ10, NAD+)
  • Neuropathy prevention (alpha-lipoic acid IVs)

Real Case Study: Jessica’s Journey to Diagnosis

Jessica, 42, experienced fatigue, dry eyes, and aching joints for years but was told her labs were “normal.” At Patients Medical, we ran comprehensive panels and discovered:

  • Positive SSA antibodies
  • Gut dysbiosis and candida overgrowth
  • Low vitamin D and zinc
  • Elevated Epstein-Barr titers
  • Estrogen dominance with low cortisol

With integrative care including gut healing, immune balancing herbs, and bioidentical hormone support, Jessica’s energy returned, her dryness eased, and her flares became rare.

Testimonials

Frequently Asked Questions

 There’s no single test. We combine antibody panels, biopsies, glandular tests, and functional diagnostics for accuracy.

 Yes. Many people are seronegative but still meet criteria based on symptoms and other labs.

 Most tests are bloodwork or non-invasive. In rare cases, a salivary gland biopsy may be suggested.

 Yes. We often identify immune dysfunction, hormone imbalance, and gut triggers before antibodies are fully positive.

 Some conventional tests may be covered. We provide superbills for partial reimbursement. Functional tests may be out-of-pocket.

 We help manage and reduce flares through anti-inflammatory diets, herbal protocols, and hormone balance.

 Yes. We offer Schirmer’s test and gland imaging as needed.

 Yes. Fatigue is often the first and most persistent symptom. We address it through mitochondrial and adrenal support.

 Sjögren’s can impact hormone balance. We work with women through fertility, pregnancy, and menopause transitions.

 Our holistic protocols are designed to address overlapping autoimmune conditions.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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