Weight Gain

When Weight Gain Won’t Respond to Diet/Exercise

For many adults, unexplained weight gain persists despite strict dieting and exercise—often signaling deeper metabolic, hormonal, or toxic burdens. At Patients Medical in NYC, we specialize in identifying and treating these hidden causes:

✔ Hormonal imbalances (thyroid, cortisol, estrogen dominance)
✔ Metabolic dysfunction (insulin resistance, mitochondrial issues)
✔ Toxin accumulation (heavy metals, endocrine disruptors)
✔ Gut microbiome disruptions (SIBO, candida overgrowth)

We don’t just help you lose weight—we restore your body’s ability to regulate it naturally.

When Weight Gain Won’t Respond to Diet/Exercise

Common Causes of Unexplained Weight Gain

Diagnostic Testing for Weight Gain

We use advanced labs to pinpoint your root causes:

Full Thyroid Panel (TSH, free T3/T4, reverse T3, antibodies)

Hormone Testing (cortisol, estrogen, testosterone, insulin)

Gut Health Analysis (stool microbiome, SIBO breath test)

Toxin & Heavy Metal Testing (urine, blood)

Metabolic Markers (fasting glucose/insulin, leptin, adiponectin)

Food Sensitivity Testing (IgG reactions to inflammatory foods)

Integrative Treatment Protocols

Hormone Optimization

  • Thyroid Support: Natural desiccated thyroid or T3/T4 combinations
  • Estrogen Detox: DIM, calcium-d-glucarate, and liver support
  • Adrenal Repair: Adaptogens (ashwagandha, rhodiola) and circadian rhythm reset

Metabolic Reset

  • Personalized Nutrition: Anti-inflammatory, low-glycemic diets tailored to your labs
  • Nutraceuticals: Berberine, alpha-lipoic acid, and inositol for insulin sensitivity
  • IV Therapy: Magnesium, glutathione, and B vitamins to support detox pathways

Gut Healing

  • Probiotic Protocols: Targeted strains (e.g., Lactobacillus gasseri for weight management)
  • Antimicrobials: Herbal antifungals/bacterials for SIBO/candida
  • Leaky Gut Repair: L-glutamine, zinc carnosine, and colostrum

Detoxification

  • Liver Support: NAC, milk thistle, and infrared sauna therapy
  • Heavy Metal Chelation: If testing reveals toxic burdens

Case Study: Lisa’s 35-Pound Transformation

Lisa, 41, gained 30 lbs in 8 months despite marathon training. Testing revealed:

  • Subclinical hypothyroidism (TSH 4.1, low free T3)
  • Estrogen dominance (low progesterone)
  • Severe magnesium deficiency

Our 4-Month Plan Included:

  1. Natural thyroid replacement + selenium support
  2. Bioidentical progesterone cream
  3. Daily magnesium glycinate + IV therapy
  4. Low-glycemic, anti-inflammatory diet

Results:

  • Lost 35 lbs (returned to pre-gain weight)
  • Energy and sleep restored
  • No more joint pain or bloating

Testimonials

Frequently Asked Questions

Yes! Chronic high cortisol increases abdominal fat storage and cravings for sugary/fatty foods.

If appropriate, but we prioritize addressing root causes first (e.g., thyroid, gut, toxins).

Hormone/metabolic changes begin in 4–6 weeks; significant weight loss typically starts by 3 months.

No. We focus on food quality, timing, and metabolic repair—not restrictive dieting.

We provide superbills for out-of-network reimbursement. Many tests (thyroid, hormones) may be partially covered.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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