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Allergies General

General Allergies: Symptoms, Types, Causes & Integrative Treatment in NYC

General allergies arise when the immune system’s regulatory circuits misfire — producing an exaggerated IgE-mediated response to harmless substances that floods your body with histamine, triggers systemic inflammation, and disrupts sleep, concentration, and quality of life far beyond a seasonal runny nose. If you feel like you are allergic to the world, there is a root-cause reason, and it can be found.

30%

of U.S. adults have allergic rhinitis

50M

Americans affected by allergies annually

3–5yr

typical immunotherapy course for desensitisation

6th

leading cause of chronic illness in the U.S.

Medically reviewed by Dr. Rashmi Gulati, MD — Medical Director, Patients Medical.

Board-certified integrative medicine physician.

Clinical Definition

General allergies — also termed allergic hypersensitivity disorders or atopic disease — are immune-mediated conditions in which sensitised individuals mount an aberrant, IgE-mediated Type I hypersensitivity reaction upon re-exposure to specific environmental antigens (allergens), including aeroallergens such as pollens, house dust mite (Dermatophagoides pteronyssinus), mold spores, animal dander, insect venoms, and latex. Mast cell and basophil degranulation releases histamine, leukotrienes (LTC4, LTD4), prostaglandins (PGD2), and cytokines (IL-4, IL-5, IL-13), producing the acute and late-phase allergic responses. In functional medicine, chronic allergic reactivity is understood to reflect a systemic immune dysregulation pattern, frequently driven by intestinal hyperpermeability, microbiome depletion, HPA-axis dysregulation, and micronutrient insufficiency, rather than a fixed genetic destiny.

Key Symptoms

Rhinorrhea and nasal congestion
Sneezing and post-nasal drip
Itchy, watery eyes (conjunctivitis)
Skin hives (urticaria) and eczema
Wheezing and respiratory symptoms
Chronic fatigue and brain fog

Primary Causes

IgE sensitisation to aeroallergens
Gut dysbiosis and leaky gut
Mold and mycotoxin exposure
Impaired immune Treg regulation
Nutrient deficiencies (Vit D, C)
Chronic stress / HPA axis dysregulation

Treatment Approach

IgE RAST & IgG food sensitivity testing
Gut microbiome repair protocol
Quercetin, Vit C, Vit D optimisation
Anti-inflammatory elimination diet
Environmental allergen reduction
IV vitamin C and glutathione therapy

What Are General Allergies?

General allergies are a category of immune-system disorders in which the body develops an exaggerated sensitivity to substances — called allergens — that would cause no reaction in most people. Common environmental allergens include tree, grass, and weed pollens; house dust mites; cat and dog dander; Alternaria and Aspergillus mold spores; and cockroach proteins. When a sensitised person encounters their specific allergen, the immune response is not simply proportionate — it is dramatically amplified, flooding tissues with inflammatory chemicals that can affect the nose, eyes, skin, lungs, and gastrointestinal tract simultaneously.

The biological mechanism begins with sensitisation: on first allergen exposure, antigen-presenting dendritic cells in the nasal or bronchial mucosa present allergen fragments to T-helper-2 (Th2) lymphocytes. These Th2 cells release interleukin-4 (IL-4) and interleukin-13 (IL-13), signalling B-cells to class-switch and produce allergen-specific immunoglobulin E (IgE) antibodies. These IgE molecules bind to high-affinity receptors (FcεRI) on mast cells throughout the body. On re-exposure, allergens cross-link these membrane-bound IgE antibodies, triggering instantaneous mast cell degranulation — a surge of histamine, prostaglandins, and leukotrienes that causes the familiar allergy symptoms within minutes.

From a functional medicine perspective, the critical question is not just “what are you allergic to?” but “why is your immune system hyper-reactive in the first place?” Decades of research point to the gut-immune axis as the central regulator of allergic reactivity. Approximately 70% of the immune system resides in the gut-associated lymphoid tissue (GALT). When the intestinal barrier is compromised — a condition called increased intestinal permeability or leaky gut — incompletely digested food proteins and bacterial endotoxins (lipopolysaccharides) cross into the bloodstream, chronically stimulating the immune system into a state of vigilance that amplifies all allergic reactions. Additionally, depletion of key regulatory T-cells (Tregs) — which normally act as the immune system’s “off switch” — allows allergic Th2 responses to run unchecked. Restoring gut integrity and Treg function is therefore as important as allergen avoidance in achieving lasting allergy remission.

Allergic diseases affect an estimated 50 million Americans and constitute the sixth leading cause of chronic illness in the United States, costing over $18 billion annually in direct medical costs. The prevalence of allergic rhinitis has more than doubled since the 1970s, a rise that cannot be explained by genetics alone and strongly implicates environmental, dietary, and microbiome changes. Women are slightly more likely than men to develop adult-onset allergies; however, children with atopic eczema, asthma, and food allergies have a significantly elevated lifetime risk of developing additional allergic conditions — a phenomenon known as the atopic march.

Mast Cells & IgE Receptors

Mast cells reside in virtually every body tissue, particularly at interfaces with the environment — nasal mucosa, skin, and gut lining. Covered with 100,000–500,000 surface IgE receptors (FcεRI), a single sensitised mast cell can degranulate instantaneously on allergen contact, releasing pre-formed histamine and synthesising leukotrienes and prostaglandins that produce the acute allergic response.

Th1/Th2 Immune Balance

In healthy immune regulation, Th1 and Th2 lymphocyte activity is balanced. Allergic individuals have a Th2-dominant phenotype in which excess IL-4, IL-5, and IL-13 production drives IgE synthesis, eosinophil recruitment, and mucus secretion. Functional medicine aims to restore Th1/Th2 balance — and enhance Treg suppressor activity — through gut microbiome optimisation and targeted anti-inflammatory nutrition.

Nasal Mucosa & Bronchial Epithelium

The respiratory mucosal barrier is the primary point of allergen contact. In sensitised individuals, this barrier is structurally compromised — tight junctions are loosened by IL-25 and TSLP (thymic stromal lymphopoietin), allowing larger allergen particles to penetrate and stimulate deeper immune cells. Chronic allergic rhinitis creates persistent mucosal oedema, sinus ostial blockage, and an inflammatory milieu that predisposes to secondary bacterial sinusitis and asthma.

Signs & Symptoms of General Allergies

Allergic immune activation is systemic — far beyond seasonal sneezing — affecting the respiratory, neurological, dermatological, and gastrointestinal systems simultaneously through shared histamine and cytokine pathways.

Respiratory & ENT Symptoms

Rhinorrhea (runny nose)

Histamine stimulates mucus gland secretion in the nasal turbinates, producing the characteristic watery nasal discharge that intensifies on allergen exposure.

Nasal congestion

Vascular dilation and submucosal oedema caused by prostaglandin D2 (PGD2) and leukotrienes narrow the nasal airway, reducing airflow and causing the blocked sensation.

Paroxysmal sneezing

Allergen stimulation of trigeminal sensory nerve endings in the nasal epithelium triggers repetitive sneezing reflexes as the body attempts to expel the perceived threat.

Post-nasal drip & chronic cough

Excess nasal mucus drains posteriorly, coating the pharynx and larynx, triggering persistent throat-clearing and a chronic dry or productive cough.

Recurrent sinusitis

Allergic mucosal oedema blocks the ostiomeatal complex — the drainage pathway of the paranasal sinuses — creating stagnant secretions that are readily colonised by bacteria.

Ear pressure and fullness

Eustachian tube dysfunction secondary to nasopharyngeal oedema impairs middle ear pressure equalisation, producing a sensation of fullness or muffled hearing.

Ocular & Dermatological Symptoms

Allergic conjunctivitis

IgE-mediated mast cell activation in the conjunctival mucosa produces bilateral itching, redness, tearing, and chemosis (conjunctival swelling) on allergen exposure.

Periorbital oedema ("allergic shiners")

Chronic nasal and periorbital venous congestion produces darkening and puffiness under the eyes — a classic sign of persistent allergen exposure or food intolerance.

Urticaria (hives)

Dermal mast cell degranulation produces localised wheals with surrounding flare (redness) through histamine-mediated vasodilation and plasma extravasation into skin tissues.

Atopic dermatitis (eczema)

A Th2-driven inflammatory skin condition in which epidermal barrier defects allow allergen penetration, producing the intensely pruritic, inflamed, and lichenified patches typical of atopic eczema.

Angioedema

Deep dermal and subcutaneous swelling, most commonly affecting the lips, eyelids, tongue, and throat, caused by bradykinin- or histamine-driven fluid extravasation into deeper tissue layers.

Pruritus (generalised itching)

Elevated systemic histamine levels activate H1 receptors on cutaneous sensory nerve endings, producing diffuse itching even in the absence of visible rash or hives.

Neurological & Cognitive Symptoms

Brain fog and cognitive impairment

Pro-inflammatory cytokines IL-1β and TNF-α cross the blood-brain barrier and impair prefrontal cortex function, reducing working memory, concentration, and processing speed.

Chronic fatigue

Persistent immune activation diverts metabolic energy toward cytokine production and tissue repair, directly reducing cellular ATP availability and driving the profound tiredness that allergy sufferers describe.

Headache and facial pressure

Sinus congestion elevates intrasinusal pressure and can refer pain across the forehead, cheeks, and orbital ridges — distinct from migraine but equally debilitating.

Sleep disruption

Histamine is a key wakefulness-promoting neurotransmitter in the hypothalamic tuberomammillary nucleus; high systemic histamine levels disrupt normal sleep architecture and cause non-restorative sleep.

Mood changes and anxiety

Neuroinflammatory signalling via the vagus nerve — the gut-brain axis — translates peripheral immune activation into central nervous system effects including increased anxiety and depressive symptoms.

Gastrointestinal & Systemic Symptoms

Nausea and abdominal cramping

Gut mast cells activated by food allergens or high systemic histamine levels impair gastric motility, increase intestinal secretions, and produce cramping, bloating, and nausea.

Diarrhoea or loose stools

Histamine acting on H1 and H2 receptors in the intestinal mucosa increases intestinal motility and secretion, accelerating gastrointestinal transit and causing loose stools in sensitised individuals.

Wheezing and shortness of breath

Leukotriene-mediated bronchospasm and mucus hypersecretion in the lower respiratory tract produces the characteristic wheeze and dyspnoea of allergic asthma — a common comorbidity of allergic rhinitis.

Low-grade fever and malaise

Pyrogenic cytokines (particularly IL-1β and IL-6) produced during significant allergic reactions can generate a mild fever and the systemic flu-like malaise that distinguishes severe allergy from a simple seasonal flare.

Weight changes

Chronic histamine elevation disrupts appetite regulation via hypothalamic H1 receptors, and systemic inflammation impairs insulin sensitivity and thyroid function, contributing to unexplained weight gain in allergy sufferers.

The 4 Major Types of General Allergies

Understanding your allergy type determines which tests, treatments, and environmental modifications will be most effective in reducing your immune reactivity.

01 Type I: Seasonal

Seasonal Allergic Rhinitis

Triggered by airborne pollens from trees (spring), grasses (summer), and weeds (autumn), seasonal allergic rhinitis produces predictable cyclical flares of rhinorrhoea, sneezing, and conjunctivitis. IgE levels against specific pollens are elevated; total IgE may be moderately raised.

This is the most common allergy type. Skin prick testing readily identifies the offending pollens, and patients often have a clear on/off pattern mirroring regional pollen calendars.

↳ Most common in adults 20–45; often first presents in childhood.

02 Type II: Perennial

Perennial Allergic Rhinitis

Year-round allergic rhinitis driven by indoor allergens — most commonly house dust mites (Dermatophagoides pteronyssinus), cockroach allergens, cat (Fel d 1) and dog (Can f 1) dander, and Aspergillus and Alternaria molds. Symptoms are constant rather than seasonal, and nasal congestion tends to dominate over rhinorrhoea.

Perennial rhinitis frequently co-occurs with asthma and eczema, and patients are at higher risk of developing chronic sinus disease.

↳ Affects all ages; pet ownership and poor indoor air quality are major risk factors.

03 Type III: Mold & Toxic

Mold Allergy & Mycotoxin Sensitivity

Allergic reactions to mold spores are common (seasonal outdoor molds, indoor water-damage molds), but a distinct and underdiagnosed problem is mycotoxin sensitivity — an inflammatory response to biotoxins produced by molds including Stachybotrys chartarum (black mold), Aspergillus, and Penicillium. Mycotoxins trigger IgE- and IgG-mediated reactions and can persist long after allergen removal.

Mold-sensitive patients frequently report extreme fatigue, cognitive dysfunction, and multiple chemical sensitivities that extend beyond respiratory symptoms.

↳ Particularly prevalent in NYC residents in older buildings with water damage history.

04 Type IV: Multi-Sensitised

Polysensitisation & Atopic Syndrome

Polysensitisation — IgE-mediated reactivity to four or more unrelated allergen categories simultaneously — represents the most immunologically complex and clinically challenging allergy phenotype. It is strongly associated with gut dysbiosis, intestinal hyperpermeability, and impaired Treg regulation. Patients frequently have concurrent asthma, eczema, food allergies, and chemical sensitivities.

Functional medicine is particularly well-suited to this category because the root-cause approach addresses the systemic immune dysregulation driving reactivity to multiple allergens simultaneously.

↳ More common in patients with prior antibiotic exposure, c-section birth, or early formula feeding.

Causes & Risk Factors for General Allergies

Allergic disease results from a convergence of multiple interacting drivers — genetic predisposition, immune dysregulation, environmental exposures, and lifestyle factors — rather than a single trigger.

01

Genetic atopic predisposition

Variants in the FCER1A gene (encoding the IgE receptor) and the IL-4 receptor alpha chain (IL4RA) create a constitutional tendency toward Th2-dominant immune responses and elevated IgE production, conferring a 2–3× increased allergy risk to children of allergic parents.

02

Gut microbiome depletion (dysbiosis)

Reduced microbial diversity — particularly loss of Lactobacillus rhamnosus, Bifidobacterium longum, and Faecalibacterium prausnitzii — impairs immune tolerance by reducing short-chain fatty acid (SCFA) production and Treg cell differentiation in the intestinal mucosa.

03

Intestinal hyperpermeability (leaky gut)

Disrupted tight junction proteins (occludin, claudin, ZO-1) allow undigested food antigens and bacterial LPS to enter systemic circulation, chronically stimulating IgE and IgG production and priming the immune system for heightened reactivity.

04

Vitamin D deficiency

The active form of vitamin D (1,25-dihydroxyvitamin D3) directly promotes Treg differentiation and suppresses Th2 cytokine production; serum 25-OH-D below 30 ng/mL is associated with significantly elevated IgE levels and increased allergy severity.

05

Overuse of antibiotics

Broad-spectrum antibiotics (particularly ampicillin, amoxicillin-clavulanate) dramatically reduce gut microbial diversity, suppressing SCFA production and impairing mucosal IgA secretion that normally neutralises inhaled allergens before immune sensitisation occurs.

06

Mold and mycotoxin exposure

Airborne spores and volatile organic compounds (VOCs) from water-damaged buildings directly activate mast cells through non-IgE pathways and induce pulmonary and systemic inflammation that amplifies all concurrent allergic reactivity.

07

Chronic psychological stress

HPA axis activation elevates cortisol, which initially suppresses immune activity; however, chronic cortisol exposure causes glucocorticoid receptor resistance, impairing cortisol’s anti-inflammatory action and shifting the immune system toward Th2 pro-allergic activation.

08

Ultra-processed diet and food additives

Dietary emulsifiers (polysorbate-80, carboxymethylcellulose) disrupt the intestinal mucus layer; artificial colorants and preservatives activate mast cells directly; and low-fibre diets deplete butyrate-producing bacteria critical to mucosal immune tolerance.

09

Early-life microbial deprivation

Caesarean birth (bypassing maternal vaginal microbiota transfer), exclusive formula feeding (limiting immune-modulating oligosaccharides), and overly sanitised early environments collectively impair the immune education that normally establishes tolerogenic responses.

10

Heavy metal and environmental toxin burden

Cadmium, arsenic, and mercury directly impair Treg function and enhance mast cell sensitivity; airborne particulate matter (PM2.5) acts as an adjuvant that enhances IgE responses to co-inhaled allergens — a significant factor for NYC urban residents.

11

Omega-3 to omega-6 fatty acid imbalance

The modern Western diet provides an omega-6/omega-3 ratio of 15:1 to 20:1, far exceeding the ancestral 4:1 ratio, driving prostaglandin E2 (PGE2) dominance that actively promotes mast cell sensitivity and Th2 immune skewing.

12

Diamine oxidase (DAO) enzyme deficiency

DAO is the primary enzyme responsible for degrading dietary and endogenous histamine in the intestinal mucosa; deficiency — caused by nutrient deficiencies (copper, vitamin B6, vitamin C) or gut mucosal damage — leads to systemic histamine accumulation that dramatically amplifies allergic symptoms.

General Allergies vs. Related Conditions

Many conditions share symptom overlap with general allergies, and correct differentiation is essential for appropriate testing and treatment. The following comparison highlights the key distinguishing features.

Feature	General Allergies	Food Allergies / Intolerance	Mast Cell Activation Syndrome (MCAS)	Chronic Sinusitis
Key immune marker	Elevated specific IgE (aeroallergens)	Elevated food-specific IgE or IgG	Elevated serum tryptase, prostaglandin D2, histamine	CT findings of mucosal thickening; often normal IgE
Best diagnostic test	IgE RAST panel + skin prick test	IgE RAST + comprehensive IgG food panel	24-hour urine prostaglandin D2 + serum tryptase	Sinus CT scan + endoscopic evaluation
Hallmark symptom	Sneezing, rhinorrhoea, conjunctivitis on allergen exposure	GI symptoms (IgE) or delayed bloating/fatigue (IgG) after eating	Flushing, tachycardia, diarrhoea triggered by multiple unrelated stimuli	Persistent facial pressure, purulent discharge, anosmia
Standard blood test detects it?	Partially (total IgE, CBC eosinophils)	Rarely (IgG panels are non-standard)	Often missed on standard panels	May show elevated CRP/ESR; normal IgE
Treatment approach	Allergen immunotherapy + gut-immune repair	Elimination diet + gut barrier restoration	Mast cell stabilisers + low-histamine diet	Saline irrigation + antibiotics; surgery for anatomical causes
Overlap with other condition	Frequently co-occurs with all three conditions	Often underlies or worsens general allergies	May be misdiagnosed as general allergies for years	Untreated allergic rhinitis is the leading sinusitis driver

Important clinical note: Mast Cell Activation Syndrome (MCAS) is a frequently missed diagnosis in patients labelled with “severe allergies.” Unlike classic IgE-mediated allergy, MCAS involves constitutive mast cell instability triggered by multiple unrelated stimuli (temperature, vibration, medications, emotional stress), producing systemic symptoms across 10 or more organ systems. If your symptoms are disproportionately severe, occur without a clear allergen trigger, or do not respond to standard allergy treatment, ask your physician about MCAS evaluation.

Is Allergy a Simple IgE Problem? The Honest Answer

There is an important ongoing clinical debate about the scope of allergic disease — specifically whether immune reactions beyond the classic IgE-mediated pathway deserve medical attention, and what role gut health plays. Understanding both perspectives helps you advocate for comprehensive care.

01 Conventional Medicine's Position

Allergy is definitively diagnosed by demonstrable IgE sensitisation (positive skin prick test or RAST). Reactions without elevated IgE are typically classified as intolerance rather than allergy.
The standard of care is symptomatic management (antihistamines, intranasal corticosteroids) and allergen immunotherapy for moderate-to-severe rhinitis or asthma.
IgG food sensitivity testing is not recognised as a validated diagnostic tool by the American Academy of Allergy, Asthma and Immunology (AAAAI).
Gut microbiome manipulation is considered investigational for allergy management, pending larger clinical trial data.
Dietary modifications beyond identified food allergies are not routinely recommended for environmental allergy management.

02 Functional Medicine's Perspective

IgE is one pathway of many. IgG-mediated reactions, direct mast cell activation, T-cell-mediated hypersensitivity, and non-immunological histamine release all contribute to the total allergy burden and deserve evaluation.
Symptomatic management does nothing to reduce immune hyper-reactivity. The question of why mast cells are over-reactive — and what can reduce that reactivity — requires a root-cause investigation.
A substantial and growing body of evidence — including randomised trials on probiotics, gut permeability, and Th2 modulation — supports microbiome-targeted allergy treatment.
Vitamin D, omega-3 fatty acids, quercetin, and diamine oxidase (DAO) supplementation have published clinical evidence supporting their use in allergy management.
Patients who address concurrent gut dysbiosis, nutrient deficiencies, mold exposure, and stress often achieve allergy remission that was not possible with conventional treatment alone.

Patients Medical’s Position: We respect and incorporate conventional allergy medicine — skin prick testing, RAST panels, and allergen immunotherapy are valuable tools we use regularly. We also recognise that these tools, used in isolation, do not identify or address the underlying immune dysregulation that makes a person allergic in the first place. Our approach combines the precision of conventional allergy diagnosis with functional medicine’s root-cause framework — evaluating gut integrity, microbiome health, nutrient status, toxic exposures, and stress physiology — to achieve outcomes that neither approach can deliver alone.

How We Diagnose General Allergies in NYC

Our comprehensive allergy evaluation goes far beyond a standard RAST panel — mapping the full terrain of immune reactivity and identifying every upstream driver.

01 Specific IgE RAST Panel (Environmental Allergens)

The IgE RAST panel measures serum immunoglobulin E antibody levels against 120+ individual environmental allergens — including regional tree, grass, and weed pollens; house dust mite species (D. pteronyssinus and D. farinae); common mold species (Aspergillus fumigatus, Alternaria alternata, Cladosporium herbarum); cat (Fel d 1), dog (Can f 1), and cockroach allergens; and insect venoms. This test definitively identifies IgE-mediated sensitisation and quantifies each reaction, guiding the formulation of custom immunotherapy protocols.

02 Comprehensive IgG Food Sensitivity Panel (184 Foods)

While not a test for classic IgE food allergy, the IgG food sensitivity panel identifies delayed immune reactions to specific foods that chronically stimulate gut mast cells and drive systemic immune activation. Elevated IgG reactivity to foods such as gluten (gliadin), casein (dairy), eggs, corn, soy, and yeast is extraordinarily common in allergy patients and frequently contributes to the total inflammatory load that makes environmental allergy symptoms more severe. Eliminating high-IgG foods allows gut mucosal healing and often produces significant reduction in environmental allergy severity within 6–8 weeks.

03 Complete Blood Count with Differential (Eosinophil & Basophil Count)

The CBC with differential provides objective evidence of allergic immune activation through elevated eosinophil count (normal: <0.5 × 10⁹/L) and basophil count. Peripheral eosinophilia (eosinophil count >0.5) is a biomarker of active allergic inflammation and is also seen in parasitic infections and eosinophilic GI conditions that can mimic allergy. Tracking eosinophil count over the course of treatment provides a measurable indicator of immune calming and treatment response

04 Mycotoxin Urine Testing (Great Plains / Mosaic Diagnostics)

Mold toxin (mycotoxin) urine testing measures urinary levels of 11 mycotoxins including ochratoxin A, aflatoxins, trichothecenes (satratoxins), zearalenone, and gliotoxin. These biotoxins, produced by common indoor molds including Stachybotrys, Aspergillus, and Penicillium species, are not detected by standard IgE mold testing but are a significant driver of severe, treatment-resistant allergies in NYC patients living or working in older buildings. Positive mycotoxin results guide environmental remediation and targeted binder therapy with cholestyramine or activated charcoal.

05 GI-MAP Stool Analysis (Gut Microbiome & Intestinal Permeability)

The GI-MAP comprehensive stool test uses quantitative PCR technology to measure the abundance of commensal bacteria, opportunistic pathogens, parasites, Candida, and H. pylori in the gut microbiome, along with secretory IgA (mucosal immunity marker), calprotectin (intestinal inflammation marker), anti-gliadin IgA (gluten reactivity), and elastase-1 (pancreatic enzyme sufficiency). Identifying specific bacterial depletions and pathogenic overgrowth allows a targeted gut restoration protocol that addresses the microbiome root cause of immune dysregulatio

Does This Sound Like You?

Check all that apply to your current experience:

I have daily nasal congestion or runny nose that is not due to a cold
My eyes are frequently itchy, red, or watery
I experience unexplained fatigue or brain fog regularly
I have skin rashes, hives, or eczema that flare unpredictably
I have recurring sinus infections (2 or more per year)
Antihistamines provide incomplete or short-lived relief
My symptoms are present year-round, not just in pollen season
I feel worse in certain buildings or after eating certain foods
I have been told my allergy tests are normal but still feel unwell

General Allergy Treatment at Patients Medical NYC

Our treatment protocol is built on a single guiding principle: lasting allergy relief requires addressing the root causes of immune dysregulation, not simply suppressing symptoms.

Gut Microbiome Restoration

The foundation of allergy treatment at Patients Medical is rebuilding the gut microbiome environment that regulates immune tolerance. Based on your GI-MAP results, we prescribe a targeted protocol of specific probiotic strains — typically including Lactobacillus rhamnosus GG, Lactobacillus acidophilus NCFM, Bifidobacterium longum BB536, and Faecalibacterium prausnitzii precursors — combined with prebiotic fibres (partially hydrolysed guar gum, arabinogalactans) and gut mucosal repair nutrients (L-glutamine, zinc carnosine, deglycyrrhizinated licorice) to restore intestinal barrier integrity and re-establish Treg-mediated immune tolerance.

L. rhamnosus GG

B. longum BB536

L-Glutamine

Zinc Carnosine

GI-MAP guided

IV Vitamin C & Glutathione Therapy

High-dose intravenous vitamin C (15–50g per infusion) provides immediate and potent natural antihistamine activity by accelerating histamine degradation via the enzyme histamine-N-methyltransferase, while simultaneously reducing mast cell reactivity through antioxidant-mediated stabilisation of mast cell membranes. Paired with intravenous glutathione (600–1200mg), which replenishes the master antioxidant depleted by chronic inflammation, our IV vitamin therapy protocol produces rapid symptom relief and a gradual reduction in baseline immune reactivity over a course of 6–10 infusions.

IV Vitamin C 15–50g

IV Glutathione

Myer's Cocktail

Mast cell stabilisation

Nutraceutical Anti-Histamine Protocol

Based on your comprehensive lab results, we design a personalised nutraceutical protocol targeting the specific mechanisms driving your allergic reactivity. Core agents include quercetin (500–1000mg daily) as a natural mast cell stabiliser; vitamin D3 (titrated to achieve serum 25-OH-D of 60–80 ng/mL) to restore Treg-mediated immune tolerance; EPA/DHA omega-3 fatty acids (2–3g daily) to shift prostaglandin synthesis away from pro-inflammatory PGE2; butterbur extract (standardised to petasines) for acute rhinitis relief; and diamine oxidase (DAO) enzyme supplementation for patients with documented histamine intolerance.

Quercetin 500–1000mg

Vitamin D3

EPA/DHA Omega-3

Butterbur

DAO Enzyme

Environmental Detoxification Protocol

For patients with positive mycotoxin testing or heavy metal burden, we implement a structured environmental detoxification protocol. This includes medical-grade binders — cholestyramine, activated charcoal, or bentonite clay — to sequester circulating mycotoxins; chelation therapy for patients with documented heavy metal toxicity; comprehensive guidance on air filtration (HEPA + activated carbon), water filtration, and building inspection for water damage; and VCS (visual contrast sensitivity) testing and MARCoNS nasal culture for patients with suspected biotoxin illness.

Cholestyramine

HEPA Filtration

Heavy Metal Testing

Chelation

Mycotoxin Binders

Anti-Inflammatory Elimination Diet

Based on your IgG food sensitivity results and clinical presentation, we implement a structured elimination diet that removes the specific foods generating your highest IgG immune reactions for a minimum of 6 weeks — long enough for intestinal mucosa regeneration (complete mucosal cell turnover takes approximately 5–7 days; however, inflammation resolution and IgG antibody clearance require 4–6 weeks). Following the elimination phase, foods are systematically reintroduced at 3-day intervals to identify which specific foods perpetuate symptoms, creating a personalised long-term eating map.

IgG-guided elimination

6-week protocol

Anti-inflammatory

Low-histamine option

Neuro-Immune Stress Modulation

Because chronic HPA-axis activation drives mast cell priming and impairs glucocorticoid receptor sensitivity — directly worsening allergic reactivity — stress regulation is a clinical intervention, not an optional lifestyle suggestion. Our protocol includes assessment of salivary cortisol diurnal pattern (4-point testing), adaptogenic herbal medicine (ashwagandha, rhodiola, eleuthero) dosed to your specific cortisol pattern, targeted neurotransmitter support (GABA, L-theanine, phosphatidylserine) for patients with high evening cortisol, and referral for evidence-based mind-body interventions including HeartMath biofeedback and mindfulness-based stress reduction (MBSR).

Salivary Cortisol Testing

Ashwagandha

Rhodiola

HeartMath Biofeedback

What to Expect: Your Treatment Timeline

Weeks 1–2	Comprehensive testing completed, initial dietary changes implemented, gut support protocol initiated. Many patients notice reduced symptom severity within the first 2–3 weeks as food triggers are removed.
Weeks 4–8	IV therapy sessions begin; nutraceutical protocol fully implemented; mycotoxin/heavy metal detoxification protocol commenced where indicated. Most patients report 40–60% reduction in overall allergy burden by week 8.
Months 3–6	Gut microbiome rebalancing consolidates; immune Th2-to-Th1 recalibration becomes measurable on repeat eosinophil counts and IgE levels. Patients typically experience significant improvement in sleep, energy, and cognitive clarity as the systemic inflammatory load reduces.
Months 6–12	Most patients achieve stable, durable improvement with maintenance doses of key supplements and dietary modifications. Repeat IgG food panel and GI-MAP guide protocol refinement at the 6-month mark.

Lifestyle Practices for Allergy Recovery

These specific, evidence-based lifestyle practices address the upstream drivers of immune hyper-reactivity — not just the symptoms.

Daily Nasal Saline Irrigation (Neti Pot or NeilMed)

Isotonic saline nasal irrigation with a neti pot or squeeze bottle twice daily physically removes allergen particles, mold spores, and pollutants from the nasal mucosa before they can trigger an immune response. Use sterile or distilled water (never tap water); add 0.5 teaspoon non-iodised salt and 0.25 teaspoon baking soda per 240ml. This practice reduces the allergen load reaching mast cells in the nasal epithelium and significantly reduces medication requirement in multiple randomised trials.

Sleep Environment Allergen Reduction

You spend one-third of your life in your bedroom — making it the single most important allergen environment to optimise. Encase mattress and pillows in allergen-barrier covers rated at ≤3 microns (ASTM standard); wash all bedding in hot water (≥55°C / 131°F) weekly to kill dust mites; install a HEPA air purifier rated for your room size (CADR ≥ 200 for an average bedroom); keep bedroom humidity at 40–50% using a dehumidifier (dust mites cannot survive below 50% relative humidity). These combined interventions can reduce dust mite allergen exposure by 95%.

Daily Parasympathetic Activation (4-7-8 Breathing)

Practice 10 minutes of 4-7-8 breathing daily: inhale through the nose for 4 counts, hold for 7 counts, exhale through the mouth for 8 counts. This specific breathing pattern activates the vagus nerve, shifts the autonomic nervous system from sympathetic (pro-inflammatory, mast-cell-priming) to parasympathetic (anti-inflammatory) dominance, and reduces circulating cortisol levels measurably. A morning session upon waking and an evening session before bed are particularly effective at recalibrating the HPA-axis diurnal pattern.

Moderate-Intensity Exercise (Not High-Intensity)

Moderate aerobic exercise (brisk walking, cycling, swimming) at 60–70% of maximum heart rate for 30–45 minutes, 4–5 days per week, produces a measurable anti-inflammatory effect by reducing circulating TNF-α and IL-6 levels and improving mucosal IgA secretion — the first line of respiratory immune defence. Crucially, high-intensity exercise (>85% max heart rate) in allergy patients can trigger exercise-induced bronchoconstriction and should be approached with caution; swimming in indoor pools (chlorinated water) is a notable trigger for some patients.

HEPA + Activated Carbon Air Filtration (Whole Home)

Install true HEPA filters rated at H13 or H14 (capturing ≥99.97% of particles ≥0.3 microns) in combination with activated carbon filters in all primary living areas. HEPA alone captures mold spores, pollen, dander, and dust mite particles, while activated carbon specifically adsorbs volatile organic compounds (VOCs), mycotoxins, and chemical irritants that worsen mast cell reactivity. Replace filters on schedule (typically every 6–12 months for HEPA, every 3 months for carbon). NYC residents should also monitor the daily Air Quality Index (AQI) and avoid prolonged outdoor exercise on high-pollution days.

Low-Histamine & Gut-Healing Evening Routine

Histamine levels are naturally elevated in the evening due to circadian variation in diamine oxidase (DAO) enzyme activity, explaining why many allergy sufferers feel worse at night. An evening anti-histamine routine includes: green tea with lemon (quercetin + vitamin C synergy for DAO support), avoiding fermented foods (wine, cheese, vinegar) after 3pm, taking DAO enzyme with the evening meal, and a sleep-time dose of magnesium glycinate (300–400mg) which has natural mast cell-stabilising properties and improves sleep quality disrupted by elevated evening histamine.

Diet & Nutrition Guide for General Allergies

Diet powerfully modulates allergic immune reactivity through three mechanisms: reducing the antigenic load on gut mast cells, providing anti-inflammatory nutrients that lower mast cell sensitivity, and supplying cofactors essential for histamine-degrading enzyme (DAO and HMNT) function. What you eat is one of the most tractable levers for changing your allergy trajectory.

The single most important dietary change for allergy sufferers:

Eliminate dietary histamine-liberators and DAO-blocking foods for 4 weeks while maximising quercetin-rich and omega-3-rich foods. The combination of reducing histamine load and increasing histamine degradation capacity produces a double-action effect that lowers the baseline inflammatory state driving allergy amplification — without any medication.

EAT — Foods That Support Allergy Recovery

Quercetin-rich foods: Onions, capers, apples (with skin), kale, and red leaf lettuce provide quercetin, the most potent natural mast cell stabiliser, at concentrations relevant to immune modulation.
Oily fish (wild salmon, sardines, mackerel): EPA and DHA omega-3 fatty acids shift prostaglandin synthesis away from pro-allergic PGE2 toward anti-inflammatory PGE3, reducing mast cell sensitivity.
Cruciferous vegetables (broccoli, cauliflower): Sulforaphane activates the Nrf2 pathway, inducing production of antioxidant enzymes that protect the nasal mucosa from oxidative damage during allergic reactions.
Turmeric (with black pepper): Curcumin inhibits NF-κB signalling — the master switch for pro-inflammatory cytokine production — reducing histamine release and IgE-mediated mast cell activation.
Bone broth and collagen peptides: Glycine and proline in bone broth directly support tight junction protein synthesis, accelerating intestinal barrier repair that reduces ongoing allergen sensitisation.
Fresh herbs (thyme, rosemary, oregano): Rich in rosmarinic acid, which has documented anti-inflammatory and mast cell-stabilising activity comparable to some pharmaceutical antihistamines in preclinical studies.
Pumpkin seeds and sunflower seeds: Provide zinc — essential for tight junction protein synthesis and DAO enzyme activity — and vitamin E, which reduces oxidative stress-driven mast cell hypersensitivity.
Locally produced raw honey (with caution): Contains trace quantities of local pollens and bee-derived compounds that may help modulate IgE sensitisation; well tolerated by most patients without bee allergy.
Fermented foods (if DAO status is confirmed adequate): Lactobacillus-fermented foods (plain yogurt, kefir, kimchi) support gut microbiome diversity and mucosal IgA production — only appropriate once DAO status is confirmed normal.

AVOID — Foods That Worsen Allergies

Fermented and aged products (wine, cheese, vinegar): Among the highest dietary histamine sources — directly loading the histamine burden and overwhelming DAO enzyme capacity in sensitive individuals.
Cured and processed meats (salami, bacon, hot dogs): Contain histamine, tyramine, and nitrates that act as mast cell degranulators and DAO inhibitors, acutely worsening symptoms within 30–90 minutes of consumption.
Alcohol (especially red wine and beer): Alcohol directly inhibits DAO enzyme activity by up to 40%, simultaneously adding dietary histamine — a dual burden that reliably worsens allergy symptoms in sensitive patients.
Gluten-containing grains (if IgG elevated): Gliadin peptides activate intestinal zonulin release, directly opening tight junctions and increasing intestinal permeability — perpetuating the leaky gut that drives ongoing allergen sensitisation.
Pasteurised cow's dairy: Beta-casein A1 protein from commercial dairy produces the opioid peptide beta-casomorphin-7, which promotes Th2 immune skewing and increases mucus production in susceptible individuals.
Refined sugar and high-fructose corn syrup: Drives gut dysbiosis through selective enrichment of pro-inflammatory bacterial species, depletes Bifidobacterium, and directly activates NF-κB — the master switch of immune inflammation.
Artificial food dyes (tartrazine, Red 40): Act as direct mast cell activators through non-IgE pathways, producing pseudo-allergic reactions including urticaria, rhinitis, and asthma in susceptible individuals.
Spinach, tomatoes, and avocado (high histamine liberators): These foods do not contain high histamine themselves but trigger mast cells to release their own histamine stores through direct degranulatory mechanisms, worsening the high-histamine state.

Related & Overlapping Conditions

General allergies rarely exist in isolation — they share immune mechanisms and frequently co-occur with these conditions, which deserve concurrent evaluation and treatment.

Asthma

Allergic asthma is the most common form of asthma and shares identical IgE-mast cell mechanisms with allergic rhinitis. The “one airway, one disease” concept holds that untreated nasal allergies directly worsen bronchial hypersensitivity — treating rhinitis effectively reduces asthma exacerbations.

Food Allergies & Sensitivities

Food IgE allergies and delayed IgG sensitivities both contribute to gut mast cell activation and systemic immune load, directly amplifying environmental allergy severity. Identifying and eliminating food immune triggers frequently produces surprising improvements in environmental allergy symptoms.

Leaky Gut (Intestinal Hyperpermeability)

The most severe form of immune-mediated food reaction, coeliac is an autoimmune response to gluten involving HLA-DQ2/DQ8 genetics, anti-tTG antibodies, and villous atrophy. Distinguishing coeliac from non-coeliac gluten sensitivity (IgG-mediated) is essential because the treatment intensity and dietary strictness required differ substantially.

Chronic Fatigue Syndrome

The neuroinflammation and mitochondrial dysfunction produced by persistent allergic immune activation are major and frequently unrecognised contributors to chronic fatigue. Resolving the allergic immune burden often produces dramatic improvements in energy levels in patients with concurrent fatigue.

Immune System Disorders

Mast Cell Activation Syndrome (MCAS), eosinophilic oesophagitis, and common variable immunodeficiency (CVID) all present with allergy-like symptoms but require distinct diagnostic and treatment approaches — a comprehensive functional medicine evaluation differentiates these conditions.

Chronic Stress & HPA-Axis Dysregulation

Chronic psychological stress directly primes mast cells for lower-threshold activation through CRH (corticotropin-releasing hormone) receptors on mast cell surfaces, explaining why allergy sufferers reliably experience worse symptoms during high-stress periods and why stress management is a medical intervention.

When to See a Doctor About General Allergies

Many people normalise allergy symptoms for years, managing with over-the-counter antihistamines and assuming “it’s just allergies.” But chronic allergic inflammation is a significant health burden with consequences for sleep, cognition, cardiovascular health, and immune function. Seek a comprehensive functional medicine evaluation if any of the following apply to you.

Seek a Functional Medicine Evaluation If:

Your allergy symptoms are present for more than 3 months of the year or are perennial (year-round)
You use nasal corticosteroids (fluticasone, budesonide) daily but still experience symptoms
Your allergy symptoms are accompanied by unexplained fatigue, brain fog, or mood changes
You have asthma and it is worsening despite current controller medication
Your symptoms are significantly worse in specific buildings or environments (possible mold

Antihistamines (cetirizine, loratadine, fexofenadine) provide incomplete or short-lived relief
You have had 2 or more sinus infections requiring antibiotics in the past 12 months
Your skin condition (eczema, hives, or rashes) appears to fluctuate with allergy severity
You have never had comprehensive allergy testing — only a standard blood panel
You have a child with eczema, food allergy, or recurrent ear infections (early functional intervention can prevent the atopic march)

🚨 Seek Emergency Medical Evaluation Immediately If: You experience throat tightness, difficulty swallowing, tongue or lip swelling, widespread hives, sudden severe wheezing, lightheadedness, or rapid heart rate after allergen exposure — these are signs of anaphylaxis, a life-threatening systemic allergic reaction. Call 911 or go to the nearest emergency room immediately. If you carry an epinephrine auto-injector (EpiPen), use it and still seek emergency evaluation. Do not wait to see if symptoms resolve on their own.

What Our Patients Say About Allergy Treatment

The following accounts reflect real patient experiences at Patients Medical. Names have been abbreviated to protect privacy. Individual outcomes vary.

"I had been on daily antihistamines and two nasal sprays for eleven years and was told 'this is just how it is.' Within eight weeks of starting Dr. Gulati's gut restoration protocol and removing my IgG trigger foods, my need for antihistamines dropped by about 80%. I genuinely did not believe the gut-allergy connection was real until it happened to me."

"My son had been missing school every spring due to allergy-triggered asthma attacks. After the mold testing revealed significant mycotoxin exposure in our apartment, we arranged remediation and started the detox protocol. His allergy season the following year was completely different — manageable instead of catastrophic. We only wish we had known about this approach years earlier."

"I came in thinking I just needed better antihistamines. What I discovered was that I was reacting to dust mites in my building, had a significant dairy sensitivity driving gut inflammation, and was vitamin D deficient. The IV therapy sessions were remarkable — each one noticeably cleared my head. Six months later I am off all allergy medications and actually feel well for the first time in years."

Explore Our Blog For More Insights

Frequently Asked Questions About Food Allergy

What is a general allergy and how does it differ from a food allergy?

A general allergy — also called an environmental or aeroallergen allergy — is an immune-mediated hypersensitivity reaction triggered by inhaled, contacted, or injected substances such as pollen, dust mites, pet dander, mold spores, insect venom, or latex. The immune system mistakenly identifies these harmless particles as threats and produces immunoglobulin E (IgE) antibodies against them. On subsequent exposures, these IgE antibodies bind to mast cells and basophils, triggering the release of histamine and other inflammatory mediators that produce the classic symptoms of sneezing, nasal congestion, itchy eyes, and skin reactions.

Food allergies, by contrast, involve an immune reaction specifically to food proteins — most commonly peanuts, tree nuts, shellfish, milk, eggs, wheat, soy, and fish — and can trigger systemic anaphylaxis with greater frequency than environmental allergens. A third category — food sensitivities — involves IgG-mediated or non-immunological reactions that cause delayed, low-grade inflammation rather than immediate acute symptoms.

At Patients Medical, we evaluate all three categories as part of a comprehensive allergy workup, because unidentified food sensitivities frequently amplify environmental allergy severity — a connection that standard allergy clinics rarely investigate.

How long does allergy treatment take to work?

The timeline for allergy relief depends heavily on the treatment approach. For conventional antihistamines and corticosteroids, symptom relief typically occurs within 30–60 minutes, but these medications do not reduce long-term immune reactivity. Allergen immunotherapy (subcutaneous injections or sublingual drops) typically requires 3–5 years of treatment, with noticeable improvement in most patients after 6–12 months.

At Patients Medical, our functional medicine protocol targets the root causes of immune dysregulation simultaneously. Patients following our gut-repair and anti-inflammatory protocols typically notice a reduction in symptom severity within 4–8 weeks, with significant improvement in immune reactivity within 3–6 months. Patients who also address concurrent mold exposure, intestinal permeability, or nutrient deficiencies tend to respond more quickly.

Complete immune recalibration — meaning a stable reduction in allergic reactivity without ongoing treatment — can take 12–24 months with a comprehensive protocol. The investment in addressing root causes, however, produces durable change rather than the indefinite symptom management required by standard approaches.

What tests diagnose general allergies?

The gold standard for diagnosing IgE-mediated allergies is the specific IgE RAST panel, which measures serum antibody levels against individual allergens. A skin prick test is a complementary in-office method. However, conventional allergy testing typically only evaluates IgE-mediated reactions and misses immune reactions driven by IgG antibodies, T-cell activation, or non-immunological histamine pathways.

At Patients Medical, our comprehensive allergy evaluation includes: a specific IgE RAST panel covering 120+ environmental allergens; a comprehensive IgG food sensitivity panel (184 foods); a complete blood count with differential to assess eosinophil and basophil counts; mold and mycotoxin urine testing for patients with suspected mold exposure; and a GI-MAP stool analysis to evaluate gut microbiome health and intestinal barrier integrity.

This multi-pathway approach identifies drivers of allergic reactivity that standard allergy testing routinely misses — explaining why many patients who receive normal results on standard panels still experience significant allergy symptoms. See our allergy testing page for full details.

Can allergies cause fatigue and brain fog?

Yes — chronic allergies are a frequently overlooked driver of persistent fatigue and cognitive impairment. The mechanisms are multiple. Histamine is a neuroactive compound; elevated histamine levels disrupt sleep architecture in the hypothalamus, leading to non-restorative sleep. The ongoing release of pro-inflammatory cytokines — particularly IL-4, IL-13, and TNF-α — directly impairs mitochondrial function, reducing cellular energy production and producing the profound tiredness allergy sufferers describe.

Nasal congestion and post-nasal drip frequently reduce overnight oxygen saturation, exacerbating daytime fatigue and cognitive impairment. Additionally, many allergy sufferers have concurrent intestinal hyperpermeability (leaky gut), which allows bacterial lipopolysaccharides (LPS) to enter systemic circulation and activate neuroinflammatory pathways, directly producing the brain fog, word-finding difficulties, and reduced processing speed that patients often attribute to stress or ageing.

At Patients Medical, we assess fatigue and cognitive symptoms in the context of the full allergy and immune picture. Resolving the underlying allergic drivers often produces dramatic improvements in energy and mental clarity — effects patients frequently describe as more transformative than their physical allergy symptom relief.

What is the difference between allergic rhinitis and a sinus infection?

Allergic rhinitis and acute sinusitis can produce nearly identical symptoms — nasal congestion, facial pressure, post-nasal drip, and fatigue — but they differ fundamentally in cause, duration, and treatment. Allergic rhinitis produces thin, watery, clear nasal discharge; itching of the nose, eyes, and throat; and sneezing. It follows a seasonal or perennial pattern, does not typically cause fever, and does not respond to antibiotics.

Acute bacterial sinusitis produces thick, coloured nasal discharge, facial pain over the sinuses, and often fever. It typically develops after a cold or upper respiratory infection and resolves with appropriate antibiotics. Importantly, untreated allergic rhinitis is the leading risk factor for recurrent sinusitis — the inflammation and mucus accumulation created by allergic reactions provide an ideal environment for bacterial overgrowth in the paranasal sinuses.

At Patients Medical, we routinely assess patients with recurrent sinusitis for underlying allergic drivers that perpetuate the cycle. Treating the allergy root cause is frequently more effective at preventing sinusitis recurrence than repeated antibiotic courses, which further disrupt the gut microbiome and compound the original problem.

How does gut health affect allergies?

The gut microbiome plays a central role in immune system education and allergic disease. The “old friends hypothesis” proposes that reduced early-life exposure to diverse microbial organisms — through antibiotic use, formula feeding, caesarean birth, and overly sanitised environments — impairs the development of immune regulatory T-cells (Tregs) that normally suppress allergic IgE responses.

Without adequate Treg activity, the immune system defaults toward a Th2 (pro-allergic) phenotype characterised by excessive IgE production and mast cell activation. Additionally, intestinal barrier dysfunction — leaky gut — allows incompletely digested food proteins and bacterial endotoxins to enter systemic circulation, triggering immune sensitisation that manifests as both food and environmental allergies.

The gut microbiome also directly regulates systemic histamine levels through the enzyme diamine oxidase (DAO); low DAO activity — associated with dysbiosis and nutrient deficiencies — impairs histamine breakdown and contributes to a chronic high-histamine state. At Patients Medical, restoring gut microbiome diversity and intestinal barrier integrity is the cornerstone of our allergy treatment protocol. See Leaky Gut Treatment for more detail.

What supplements and natural treatments support allergy recovery?

Several evidence-based nutraceuticals have demonstrated significant efficacy in modulating allergic immune responses. Quercetin (500–1000 mg daily) inhibits mast cell degranulation and histamine release, functioning as a natural mast cell stabiliser. Vitamin C (1000–3000 mg daily) acts as a natural antihistamine by increasing enzymatic breakdown of histamine. Butterbur extract (standardised to 8 mg petasines) has been shown in randomised controlled trials to reduce nasal allergy symptoms comparably to cetirizine.

Bromelain (400–500 mg daily), derived from pineapple, reduces nasal inflammation and improves sinus drainage. Probiotics containing Lactobacillus rhamnosus GG and Lactobacillus acidophilus have demonstrated reductions in allergic rhinitis severity in multiple clinical trials. Diamine oxidase (DAO) enzyme supplementation supports histamine breakdown in patients with documented DAO deficiency. Vitamin D (maintain serum 25-OH-D at 60–80 ng/mL) is essential for Treg differentiation. Omega-3 fatty acids (EPA + DHA, 2–3 g daily) reduce mast cell sensitivity by shifting prostaglandin synthesis away from pro-inflammatory PGE2.

At Patients Medical, all supplement protocols are individualised based on comprehensive testing results — including IgG food panels, nutrient levels, and microbiome analysis — rather than generic recommendations. See our allergy treatments page for more information.

Ready to Understand Your Allergies?

At Patients Medical, we don’t just manage allergy symptoms — we map the full landscape of your immune reactivity and build a personalised protocol to address every identified driver, from gut microbiome to mold exposure to nutrient deficiencies.

Call us at (212) 794-8800 · 800 Second Avenue, Suite 900, New York, NY 10017

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

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1148 Fifth Avenue, Suite 1B New York, NY 10128

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