Supplements for Leaky Gut

Introduction: Why Leaky Gut Needs a Root-Cause Approach

Leaky gut—also known as intestinal permeability—is a condition where the gut lining becomes compromised, allowing toxins, microbes, and undigested food to escape into the bloodstream. This can lead to systemic inflammation, autoimmune reactions, food sensitivities, and even hormone imbalances.

At Patients Medical in NYC, we go beyond generic digestive care. Using advanced testing and natural supplementation, we help repair the gut lining, restore the microbiome, and calm the immune system—treating the root cause, not just symptoms.

What Is Leaky Gut Syndrome?

Leaky gut occurs when the tight junctions of the small intestine become loose, allowing harmful particles to leak into the bloodstream. It’s often overlooked by conventional medicine, yet linked to:

  • Autoimmune conditions (Hashimoto’s, rheumatoid arthritis)
  • IBS, bloating, constipation, diarrhea
  • Skin issues (eczema, acne)
  • Brain fog and fatigue
  • Hormonal imbalances
  • Food sensitivities
  • Mood disorders (anxiety, depression)

Common Symptoms of Leaky Gut:

Root Causes Behind Leaky Gut

Functional medicine aims to uncover what’s weakening your intestinal barrier. Common root causes include:

  • Poor diet: Processed foods, sugar, alcohol, gluten
  • Chronic stress: Elevates cortisol, reduces gut immunity
  • Overuse of antibiotics or NSAIDs
  • Gut dysbiosis (imbalance in good vs. bad bacteria)
  • Mold exposure, heavy metals, or environmental toxins
  • Infections: Candida, parasites, or H. pylori
  • Nutrient deficiencies: Zinc, glutamine, vitamin D

Diagnostic Testing We Use

At Patients Medical, we use advanced diagnostics to assess gut health and tailor your supplement plan:

Comprehensive stool analysis (microbiome, inflammation, infections)

Zonulin testing (marker for gut permeability)

Food sensitivity and IgG panels

Organic acid test (OAT)

Inflammatory markers (CRP, calprotectin)

SIBO breath test

Top Physician-Guided Supplements for Leaky Gut Repair

Our programs are tailored to your age, skin type, severity of marks, and test results. Here’s how we address stretch marks naturally and effectively:

⦿ L-Glutamine

An amino acid that fuels intestinal cells and promotes tissue healing.

⦿ Zinc Carnosine

Helps tighten gut junctions and reduce inflammation.

⦿ N-Acetyl Glucosamine (NAG)

Supports mucosal repair and calms immune responses.

⦿ Deglycyrrhizinated Licorice (DGL)

Soothes gut lining and supports adrenal function.

⦿ Slippery Elm & Marshmallow Root

Herbal mucilaginous agents that coat and protect the intestinal lining.

⦿ Butyrate

A postbiotic that feeds colon cells and reduces gut inflammation.

⦿ Probiotics (multi-strain, soil-based or spore-forming)

Restore microbial balance—essential for long-term gut healing.

⦿ Prebiotics (inulin, FOS, PHGG)

Feed good bacteria and support mucosal health.

⦿ Vitamin D3 + K2

Crucial for immune modulation and gut barrier strength.

Integrative Therapies That Enhance Supplement Outcomes

Customized gut-healing diets (gluten-free, low FODMAP, GAPS-inspired)

Anti-fungal or anti-parasitic herbs if needed

IV nutrient therapy for faster gut lining repair

Acupuncture and stress relief programs

Bioidentical hormones if cortisol or thyroid issues are present

Real Case Study: Reversing Leaky Gut and Autoimmunity

Samantha, age 36, presented with bloating, Hashimoto’s, and skin rashes. Her labs revealed leaky gut, low secretory IgA, and high Candida levels.

We implemented a 12-week protocol including:

  • L-glutamine + DGL + zinc carnosine
  • Antifungal herbal therapy
  • Dairy- and gluten-free diet
  • Soil-based probiotics
  • Weekly nutrient IVs

Results:

  • Skin cleared by week 5
  • Energy and focus dramatically improved
  • Gut symptoms resolved

Antibodies dropped by 40%

Testimonials

Frequently Asked Questions

 Yes—when targeted and dosed correctly. We base all plans on lab results and symptoms.

 Most protocols last 8–16 weeks. Complex cases may take 6+ months.

 Often yes—at least temporarily, especially in autoimmune or severe inflammation cases.

 No. Once the gut lining heals and inflammation resolves, we taper or stop many supplements.

 Yes—when supervised. We cross-check everything you’re taking.

 Yes, we offer pediatric-safe formulations and gut healing plans.

 We test to see if they’re helping—or need to be switched to more targeted strains.

 They’re not required but are highly effective in advanced or stubborn cases.

 Absolutely. We often see symptom clusters improve together with gut repair.

 We are out-of-network but provide superbills for reimbursement. Lab testing may be partially covered.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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