Best supplements for Lyme Disease?

Introduction: Why Lyme Disease Needs a New Approach

Lyme disease is often misunderstood, misdiagnosed, and mistreated. At Patients Medical in New York City, we specialize in identifying the root causes of lingering Lyme symptoms and tailoring natural, integrative treatment protocols that go far beyond antibiotics.

Whether you’re in the early stages or battling chronic Lyme, our functional medicine approach uses targeted supplements, detox strategies, and immune support to help your body heal from the inside out.

What Is Lyme Disease?

Lyme disease is a bacterial infection caused by Borrelia burgdorferi, transmitted through the bite of infected ticks. While early symptoms often resemble the flu or a rash, Lyme can evolve into a complex, multi-system illness that impacts the nervous system, joints, brain, and immune function—especially when not treated early or fully eradicated.

Common Co-infections

Many patients also carry additional tick-borne pathogens like:

  • Babesia
  • Bartonella
  • Ehrlichia
  • Mycoplasma

These co-infections require different treatment strategies.

Common Symptoms of Lyme Disease:

Root Causes: Why Do Some People Stay Sick After Treatment?

Lyme is not always cured with one round of antibiotics. Many patients develop Post-Treatment Lyme Disease Syndrome (PTLDS) or chronic Lyme due to:

  • Incomplete treatment of all bacterial forms (spirochete, cyst, biofilm)
  • Suppressed immune response
  • Inflammatory and autoimmune reactions
  • Toxin accumulation from die-off (Herxheimer reactions)
  • Gut damage and dysbiosis from prolonged antibiotic use

Mitochondrial dysfunction and oxidative stress

Advanced Diagnostic Testing We Use

We go beyond standard testing to uncover the full picture of Lyme and its co-infections:

Western Blot and ELISA (with interpretation beyond CDC cutoffs)

IGeneX and Galaxy Lyme panels

PCR and DNA sequencing for co-infections

Inflammatory markers (CRP, cytokines)

Immune system profiling (CD57 count, NK cells)

Gut microbiome and leaky gut panels

Heavy metal and mycotoxin testing

Mitochondrial and oxidative stress markers

Best Supplements for Lyme Disease

Cat’s Claw (Uncaria tomentosa)

A powerful herbal antimicrobial shown to fight Borrelia and support immune modulation.

Japanese Knotweed

Rich in resveratrol, it helps reduce inflammation, protect blood vessels, and cross the blood-brain barrier to reach neurological Lyme.

Andrographis

Known for its broad-spectrum antimicrobial and antiviral effects, often included in herbal Lyme protocols.

Monolaurin

Derived from coconut, this natural fat disrupts biofilms and supports antiviral and antibacterial immunity.

Glutathione (Liposomal or IV)

The body’s master antioxidant, critical for detoxifying neurotoxins and reducing oxidative stress from Lyme die-off.

Alpha-Lipoic Acid

Supports nerve health and mitochondrial repair, commonly impaired in chronic Lyme.

Probiotics

Restores gut balance after antibiotics and supports immunity. Look for high-CFU, multi-strain formulas.

Vitamin D3 + K2

Modulates immune response and reduces inflammation. Most Lyme patients are deficient.

Magnesium Glycinate

Supports nerve health and mitochondrial repair, commonly impaired in chronic Lyme.

Curcumin (Turmeric Extract)

A potent anti-inflammatory that supports joint health, brain clarity, and immune modulation.

Integrative Treatments for Lyme Disease

Nutritional Therapy

  • Anti-Inflammatory Diets: Diets rich in vegetables, healthy fats, and lean protein to reduce inflammation and support detoxification.
  • Supplementation for Detoxification: Including herbs and nutrients that support liver detox, like milk thistle and glutathione.
  • Gut Health Support: Probiotics and prebiotics to restore gut health, which can be compromised by both Lyme disease and its treatment.

IV Vitamin Therapy

  • High-Dose Vitamin C: To support immune function and reduce oxidative stress.
  • Magnesium and B Vitamins: To help alleviate fatigue and muscle pain.
  • Glutathione: A powerful antioxidant to help detoxify the body and support liver function.
  •  

Herbal & Nutraceuticals

  • Andrographis: Known for its immune-boosting properties and effectiveness in treating Lyme co-infections.
  • Cat’s Claw: A potent herb shown to help fight Lyme disease and reduce inflammation.
  • Curcumin: An anti-inflammatory compound found in turmeric that helps reduce pain and improve cognitive function.
  • Omega-3 Fatty Acids: For reducing inflammation and supporting brain health.
  •  

Stress Reduction & Mental Health Support

  • Meditation and Mindfulness: To reduce stress and improve mental clarity.
  • Acupuncture: Helps alleviate pain and support overall immune function.
  • Adaptogenic Herbs: Such as Rhodiola and Ashwagandha to balance stress hormones and improve energy levels.

Hormone Balancing

  • Bioidentical Hormone Therapy (BHRT): To balance hormones and restore energy levels.
  • Thyroid Optimization: To support healthy thyroid function, which is often impacted by chronic infections.

Real Case Study: Amanda’s Journey with Chronic Lyme

Amanda, age 34, had seen over 12 specialists for fatigue, brain fog, and muscle pain. Standard tests were “normal,” but she felt progressively worse.

At Patients Medical, we discovered:

  • Positive Borrelia and Babesia co-infection
  • Severe magnesium deficiency
  • Gut dysbiosis and yeast overgrowth
  • Adrenal burnout

Amanda’s integrative plan included:

  • Herbal Lyme protocol with Cat’s Claw and Japanese Knotweed
  • IV Glutathione + B-complex
  • Antifungal gut cleanse
  • Mitochondrial support and adrenal adaptogens

Three months in, Amanda reported 70% improvement in energy, clearer thinking, and less joint pain. She continues to progress and is back to work full-time.

Testimonials

Frequently Asked Questions

 Supplements support healing but are typically part of a larger integrative plan that may include herbal antimicrobials, detox strategies, and sometimes antibiotics.

 Yes. We carefully design your regimen to be compatible with medications and reduce side effects or resistance.


No. Most are used short to mid-term to correct imbalances and support recovery. Maintenance regimens are minimal.

 We monitor closely to prevent or minimize die-off symptoms through binders, hydration, and pacing.

 Absolutely. We tailor specific protocols based on lab-confirmed co-infections.

 We recommend testing before prescribing supplements. Your plan is always customized to your results.

 Yes, which is why physician oversight is essential. We balance immune modulation carefully.

 Yes. We only use high-quality, medical-grade brands with proven safety and potency.

 Yes—with modified doses and protocols. We treat children with Lyme using age-appropriate care.

 Supplements are not typically covered. However, we provide superbills for visits and some testing may qualify.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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