How is Depression diagnosed?

Introduction: Why Depression Needs a New Approach

Depression affects over 20 million Americans, yet too often, diagnosis and treatment begin and end with a prescription. At Patients Medical in New York City, we believe that depression is more than a chemical imbalance—it’s a symptom of deeper physiological, emotional, and lifestyle issues.

We use advanced testing and a functional medicine lens to identify the root causes behind your depression—so we can help you heal naturally and sustainably.

We treat the whole person—not just the mood.

What Is Depression?

Depression (also called major depressive disorder) is a common but complex mental health condition that affects how you feel, think, sleep, eat, and function. It ranges from mild to severe and may be persistent or episodic.

Types of Depression Include:

  • Major Depressive Disorder (MDD): Lasts two weeks or more and impacts daily life
  • Persistent Depressive Disorder (Dysthymia): Chronic low mood lasting two years or longer
  • Seasonal Affective Disorder (SAD): Triggered by low light during fall/winter
  • Postpartum Depression: Occurs after childbirth
  • Bipolar Depression: Part of bipolar disorder mood swings

Common Symptoms of Depression

You don’t have to experience every symptom to be diagnosed with depression. Look for:

Root Causes: Why Are You Depressed?

Functional medicine seeks to understand why the brain and body are out of balance. For depression, contributing root causes may include:

  • Nutrient deficiencies (vitamin D, B12, folate, omega‑3s, magnesium)
  • Thyroid dysfunction or adrenal fatigue
  • Leaky gut and gut-brain axis imbalances
  • Chronic inflammation and cytokine activity in the brain
  • Hormonal imbalances (cortisol, estrogen, testosterone, progesterone)
  • Mitochondrial dysfunction affecting brain energy
  • Sleep disruption and circadian rhythm imbalances
  • Toxin exposure (mold, heavy metals, environmental chemicals)
  • Unresolved emotional trauma or stress

Diagnostic Testing We Use

At Patients Medical, we go far beyond a checklist or questionnaire. We use comprehensive diagnostics to uncover the physiological, biochemical, and environmental roots of depression:

In-depth hormone panels (thyroid, cortisol, estrogen, testosterone, DHEA)

Nutrient and neurotransmitter testing (B vitamins, magnesium, zinc, amino acids, serotonin, dopamine, GABA)

Gut health testing (stool microbiome analysis, leaky gut, candida)

Inflammatory markers (CRP, homocysteine, IL-6)

Mitochondrial function and energy metabolism testing

Food sensitivity and allergy panels

Heavy metal, mold, and environmental toxin screening

Integrative Treatments for Depression

Nutritional Therapy

We use food as medicine to reduce inflammation and restore neurotransmitter balance:

  • Anti-inflammatory diets (Mediterranean, elimination-based)
  • Gut-friendly foods (fermented foods, bone broth)
  • Nutrient-dense meal plans tailored to your deficiencies

IV Nutrient Therapy

IV infusions can provide rapid support, especially for patients who are severely depleted:

  • B vitamins and magnesium for nervous system support
  • Vitamin C, amino acids, glutathione
  • NAD+ therapy for brain energy and clarity

Herbal & Nutraceutical Support

We recommend evidence-based natural support, such as:

  • Omega‑3 fatty acids
  • 5-HTP, SAM-e, and L-tryptophan
  • Rhodiola, ashwagandha (adaptogens)
  • St. John’s wort (under supervision)
  • Magnesium, zinc, inositol

Hormone & Adrenal Balancing

  • Bioidentical hormone therapy
  • Thyroid optimization
  • Adrenal restoration protocols

Mind-Body & Stress Therapies

We provide:

  • Acupuncture
  • Guided breathwork and meditation
  • Neurofeedback and vagus nerve stimulation
  • Cognitive Behavioral Therapy (CBT) referrals as needed

Real Case Study: Emily’s Return to Joy

Emily, 36, came to us with chronic fatigue, low mood, anxiety, and brain fog. She had tried antidepressants but didn’t feel like herself. Functional testing showed low thyroid function, vitamin D deficiency, and poor gut health.

Her customized plan included:

  • Gluten- and dairy-free anti-inflammatory diet
  • Vitamin D and B-complex IVs
  • Probiotics and gut-healing protocol
  • Stress reduction and breathwork sessions
  • Low-dose thyroid support

Results after 10 weeks:

  • Energy returned, mood lifted
  • No longer needed naps to get through the day
  • Emotional stability and resilience restored

Testimonials

Frequently Asked Questions

Yes—imbalances in B12, D, iron, thyroid, or sex hormones are common causes of depression we treat.

Yes—we provide functional solutions that may reduce the need for medication. However, we always collaborate with your psychiatrist or primary provider.

We look at the body and brain. We use lab testing, gut healing, and nutritional psychiatry to restore balance holistically.

.

We can still help. Our therapies often complement existing prescriptions and improve overall outcomes.

Yes—we test for MTHFR, COMT, and other genes that impact neurotransmitter metabolism.

Yes—gut inflammation and immune reactivity to foods can influence mood through the gut-brain axis.

Most patients begin feeling improvements in 3–6 weeks, with deeper healing in 2–3 months.

Yes—we offer hormone-safe, drug-free support tailored to pregnant or breastfeeding individuals.

We specialize in chronic, treatment-resistant depression using a completely personalized approach.

We are out-of-network but provide superbills. Some labs and diagnostics may be partially reimbursed.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

Make an Appointment