Is depression a disease?

Introduction: Why Depression Demands a New Perspective

Depression is often dismissed as a “mental health issue”—but functional medicine shows it’s deeply rooted in physiological, lifestyle, gut, and hormonal factors. At Patients Medical in New York City, we go beyond symptom relief. We address underlying imbalances to restore mood naturally, sustainably, and holistically.

We treat the whole person—not just the diagnosis.

What Is Depression—and Is It a “Disease”?

Yes. Depression is a diagnosable medical condition recognized by major medical authorities (DSM-5, ICD-10). Its manifestations—persistent low mood, cognitive changes, and physical symptoms—stem from real biological and environmental disruptions.

But depression isn’t a one-dimensional illness. It’s a complex interplay of:

  • Neurochemical shifts (such as serotonin, dopamine imbalance)
  • Inflammation & oxidative stress
  • Hormonal and metabolic dysregulation
  • Gut-brain axis disturbances
  • Nutrient deficits & energy system dysfunction

Labeling it strictly a “mental illness” misses the deeper physiology.

Common Symptoms of Depression

Depression can present as:

Root Causes: What Drives Depression?

Functional medicine reveals multiple triggers behind depressive symptoms:

  • Nutrient shortages (B‑vitamins, vitamin D, omega‑3 fatty acids, magnesium, zinc)
  • Hormonal imbalance (thyroid dysfunction, HPA-axis stress, sex hormone shifts)
  • Gut-derived inflammation and barrier leaking
  • Chronic immune activation (elevated CRP, IL‑6)
  • Energy production issues at the mitochondrial level
  • Environmental toxic burden (mold, metals)
  • Sleep and circadian misalignment
  • Unresolved stress or trauma

Diagnostic Testing We Use

We use in-depth testing to uncover what’s really going on:

Comprehensive hormone panels: thyroid, cortisol rhythm, sex hormones

Nutritional and neurotransmitter markers

Gut microbiome, leaky gut assessments

Inflammatory & oxidative stress indicators

Mitochondrial function assays

Food sensitivity and environmental toxin testing

Genetic insights (MTHFR, COMT, MAO)

Integrative Treatments for Depression

Nutrition & Gut Health

  • Anti-inflammatory, whole-food diet
  • Gut-healing protocols (collagen, fermented foods, probiotics)
  • Elimination diets as needed

IV Nutrients & Supplementation

  • Glutathione, vitamin C, NAD+ via IV for detox, energy
  • Oral daily support: vitamin D, B complex, omega‑3s, magnesium

Herbal & Nutraceutical Interventions

  • SAM‑e, 5‑HTP, inositol, and adaptogens (ashwagandha, rhodiola)
  • GABA and L‑theanine for calm and sleep

Hormone & Adrenal Balance

  • Address thyroid dysfunction
  • Normalize cortisol patterns
  • Provide bio-identical hormone support when indicated

Mind‑Body Therapies & Lifestyle

  • Encourage mindfulness, meditation, neurofeedback
  • Acupuncture to rebalance nervous system
  • Exercise, sleep routines, and stress management

Detox & Environmental Support

  • Gentle liver detox
  • Mold and heavy metal elimination
  • Functional genetic detox optimization

Real Case Study: Emma’s Mental Rebirth

Emma, 37, had minor depressive symptoms that she believed were “normal.” But testing showed low B12, vitamin D, mild hypothyroidism, inflammation, and gut imbalance.

Her tailored care included:

  • Anti-inflammatory meals + vitamin supplementation
  • IV glutathione and NAD+
  • Thyroid and adrenal support
  • Sleep/circadian reset and acupuncture

Results:
Within 10 weeks, Emma felt more emotionally balanced, focused, and energized—without medication.

Testimonials

Frequently Asked Questions

Yes—it’s recognized by medical standards but often has treatable physiological roots.

 

Many patients restore stability through diet, supplements, and root-cause healing—under physician guidance.

Not necessarily. We collaborate with your prescriber and carefully taper as stability is achieved.

Initial mood and energy improvements in 4–6 weeks; full restoration can take months.

Yes—they’re evidence-based and individualized, with attention to nutrient-medication safety.

Yes—labs illuminate key imbalances that symptom-based approaches often miss.

Absolutely—we specialize in complex, persistent mood issues.

We’re out-of-network but offer superbills. Many labs may be reimbursable.

Yes—nutritional, lifestyle, and detox protocols are tailored for maternal mental health.

Contact us to schedule an initial consultation and root-cause assessment.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

Make an Appointment