What are the first signs of Depression?

Introduction: Why Depression Needs a New Approach

Depression often starts quietly—fatigue, disinterest, disrupted sleep—but left unaddressed, it can progress into a life-altering condition. At Patients Medical in New York City, we offer an integrative approach that doesn’t just mask symptoms. We uncover the root causes—biochemical, hormonal, environmental, and emotional—and help you rebalance your mental health naturally.

We treat the whole person—not just the brain chemistry.

What Is Depression?

Depression is a mood disorder that causes persistent feelings of sadness, hopelessness, and loss of interest in daily activities. It affects how you think, feel, and function.

There are many types:

  • Major Depressive Disorder (MDD): Characterized by a deep, ongoing sadness and low energy that lasts at least two weeks.
  • Persistent Depressive Disorder (Dysthymia): A chronic, low-grade depression that lasts for two years or more.
  • Postpartum Depression: Affects women after childbirth due to hormonal shifts and emotional stress.
  • Seasonal Affective Disorder (SAD): Depression triggered by seasonal changes, typically in winter.
  • Bipolar Depression: Alternating episodes of depression and mania.

 

Common Symptoms of Depression

Everyone experiences depression differently. Some common signs include:

Root Causes: Why Am I Depressed?

Functional medicine aims to uncover the “why” behind mental health challenges. Potential root causes of depression include:

  • Inflammation: Chronic inflammation affects brain chemistry.
  • Gut Dysbiosis: 90% of serotonin is made in the gut. An imbalanced microbiome can trigger depression.
  • Nutrient Deficiencies: Low levels of B12, folate, vitamin D, zinc, or magnesium can impair mood.
  • Hormonal Imbalances: Thyroid, cortisol, estrogen, and testosterone all impact mental wellness.
  • Toxin Exposure: Heavy metals and mold can disrupt the nervous system.
  • Unresolved Trauma or Stress: Chronic psychological stress contributes to mood instability.
  • Genetic Variants: MTHFR and other gene mutations affect neurotransmitter metabolism.

Diagnostic Testing We Use

We use in-depth testing to uncover what’s really going on:

Neurotransmitter and hormone panels (serotonin, dopamine, cortisol, thyroid)

Micronutrient testing (B12, magnesium, omega-3s, etc.)

Inflammatory markers (CRP, homocysteine)

Gut microbiome and leaky gut testing

Heavy metal and toxin screening

Genetic testing (MTHFR, COMT, etc.)

Functional brain mapping (in select cases)

Integrative Treatments for Depression

Personalized Nutrition Plans

We customize anti-inflammatory, brain-supportive diets that may include:

  • Whole-food based Mediterranean or Paleo plans
  • Elimination diets to identify food sensitivities
  • Omega-3 fatty acid-rich meals
  • Gut-healing foods and probiotics

 

IV Nutrient Therapy

Targeted IV infusions support neurotransmitter production and mitochondrial health. Ingredients may include:

  • B-complex vitamins (especially B6, B12)
  • Magnesium
  • Vitamin C
  • Amino acids like tryptophan and tyrosine

 

Herbal & Nutraceutical Support

We prescribe evidence-based supplements for brain chemistry and mood balance:

  • SAM-e
  • St. John’s Wort (where appropriate)
  • 5-HTP
  • Rhodiola rosea
  • Omega-3 fish oil
  • Vitamin D3

 

Mind-Body Therapies

We offer holistic stress relief through:

  • Acupuncture
  • Guided meditation and mindfulness
  • Adaptogenic herbs (Ashwagandha, Holy Basil)
  • Biofeedback and neurofeedback (where indicated)

Hormone Balancing

We identify and treat imbalances in:

  • Thyroid hormones
  • Estrogen and progesterone
  • Cortisol and DHEA
  • Testosterone (for men and women)

Gut Restoration

Healing the gut helps regulate mood by improving neurotransmitter production and reducing inflammation. We use:

  • Probiotics and prebiotics
  • Gut-repairing nutrients like glutamine and zinc
  • Stool analysis-guided protocols

Real Case Study: Jason’s Recovery Story

Kevin, 31, felt “off” for six months—tired, unmotivated, and socially withdrawn. His labs revealed low vitamin D, adrenal fatigue, and borderline hypothyroidism.

We crafted a care plan including:

  • Nutrient IVs and supplements
  • Cortisol regulation with herbal adaptogens
  • Clean eating plan with mood-stabilizing nutrients
  • Weekly acupuncture for anxiety and sleep

Outcome: Within 8 weeks, Kevin regained energy and motivation—and avoided antidepressant prescriptions altogether.

Testimonials

Frequently Asked Questions

Not always—they may mimic fatigue, low motivation, or sleep issues. That’s why testing is crucial.

Yes, by treating root causes early, many patients prevent worsening mental health.

Absolutely. Our care plans prioritize natural, functional strategies and only use medications when needed.

We’re out-of-network, but we provide superbills for reimbursement. Some labs may be partially covered.

Most patients feel improvement within 4–8 weeks when addressing underlying causes.

Yes. Cortisol, thyroid, and sex hormones are major mood regulators—and we treat them holistically.

An imbalanced gut can cause inflammation that impacts your mood, memory, and energy levels.

Yes, every plan is tailored to your lab results, symptoms, medical history, and goals. No two treatment protocols are alike.

We often recommend therapy alongside our protocols for best outcomes.

Yes—our protocols often improve anxiety and depression together.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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