What causes Lupus?

Introduction: Why Lupus Needs a Deeper Look

Lupus is more than an autoimmune label—it’s a signal that something deeper is off-balance in the body. While traditional care often focuses on suppressing symptoms, we take a different approach at Patients Medical in NYC.

We ask: Why did your immune system go rogue in the first place?

Our integrative team looks beneath the surface to identify root causes, triggers, and imbalances—then builds a customized healing plan that supports your body from the inside out.

What Is Lupus?

Lupus (Systemic Lupus Erythematosus or SLE) is an autoimmune condition in which the immune system attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and more. Because it presents differently in every person, understanding what caused your lupus is essential for effective, lasting care.

What Causes Lupus?

There’s no single cause of lupus. It typically results from a combination of genetic vulnerability and environmental, hormonal, and lifestyle triggers. Here are some of the most common contributors:

What Causes Lupus?

Genetics
People with certain HLA gene variations are more likely to develop lupus. However, genes alone don’t determine your fate—they just set the stage.

Viral Infections (e.g., Epstein-Barr Virus)
Many lupus patients have a history of chronic or reactivated viruses like EBV, which may trigger immune confusion and long-term inflammation.

Leaky Gut & Microbiome Imbalance
Poor gut health allows toxins and proteins to leak into the bloodstream, overstimulating the immune system—a major driver in autoimmunity.

Toxins & Environmental Exposures
Heavy metals, mold toxins, pesticides, plastics, and endocrine disruptors can trigger or worsen lupus flares by burdening the immune and detox systems.

Hormonal Imbalances
Estrogen dominance, adrenal fatigue, and thyroid dysfunction are common in lupus patients—especially women. Hormonal chaos can exacerbate inflammation.

Chronic Inflammation
Unresolved inflammation—due to food sensitivities, poor sleep, or stress—keeps the immune system in overdrive.

Chronic Stress & Trauma
Emotional stress is more than mental—it’s biochemical. Elevated cortisol, trauma, and nervous system dysregulation are major lupus triggers.

Diagnostic Testing We Use

At Patients Medical, we go far beyond basic labs. We use cutting-edge diagnostic tools to map out your unique immune profile and uncover the “why” behind your lupus:

ANA (Antinuclear Antibodies) and anti-dsDNA

Anti-Smith, anti-Ro/SSA, anti-La/SSB antibodies

ESR, CRP (inflammation markers)

Complement levels (C3, C4)

Vitamin D, zinc, omega‑3s, iron panel

Gut health testing (microbiome, leaky gut, Candida)

Hormone panels (cortisol, estrogen, thyroid)

Viral load testing (e.g., EBV, CMV)

Integrative Treatments for Lupus

Nutritional Therapy

We design anti-inflammatory, immune-calming diets to reduce flare frequency and intensity:

  • Autoimmune Protocol (AIP) or modified elimination diets
  • Whole-food, gluten- and dairy-free meals
  • Gut-healing nutrients: bone broth, collagen, L-glutamine

IV Vitamin Therapy

IVs help restore balance and support detoxification:

  • High-dose glutathione for antioxidant support
  • Vitamin C and magnesium
  • B-complex and vitamin D
  • Alpha-lipoic acid (ALA) for mitochondrial support

Herbal & Nutraceuticals

Targeted supplements to modulate immune response:

  • Curcumin, quercetin, and resveratrol
  • Omega‑3s for inflammation
  • Probiotics and prebiotics
  • Adaptogens like ashwagandha and rhodiola
  • Antiviral herbs for EBV or other triggers

 Gut & Immune Restoration

  • Comprehensive gut healing protocols
  • Mold and metal detox (when applicable)
  • Functional probiotics and antimicrobial botanicals

Hormone Balancing & Stress Reduction

  • Adrenal and thyroid support
  • Gentle hormone optimization
  • Acupuncture, breathwork, and guided meditation

Case Study: Elena’s Lupus Turnaround

Elena, 39, had SLE with frequent rashes, fatigue, and brain fog. She was on steroids but still flaring monthly. Our testing found:

  • EBV reactivation
  • Mold toxins in her home
  • Elevated estrogen
  • Leaky gut and dysbiosis

Her plan included:

  • Mold detox and gut repair protocol
  • Antiviral botanicals and glutathione IVs
  • Hormone balancing with herbs
  • Trauma-focused therapy

In just 4 months, her rashes stopped, energy improved, and she tapered off prednisone with her rheumatologist’s support.

Testimonials

Frequently Asked Questions

Lupus often results from a combination of genetic risk and environmental triggers—like infections, toxins, and hormone imbalances—that cause immune dysregulation.

Chronic stress can significantly influence the immune system and may contribute to both the onset and worsening of lupus.

You can inherit a predisposition, but lifestyle and environmental factors determine whether lupus becomes active.

Yes. Leaky gut and microbiome imbalance are major immune system triggers and can worsen or even initiate autoimmune diseases like lupus.

Latent infections like Epstein-Barr virus are strongly linked to lupus in many patients. Identifying and managing these can reduce flares.

Hormonal fluctuations—especially involving estrogen and cortisol—can drive inflammation and trigger symptoms, particularly in women.

Absolutely. Exposure to heavy metals, mold, and endocrine disruptors can provoke immune dysfunction and exacerbate autoimmune activity.

Yes. Emotional trauma and chronic stress can disrupt immune regulation and are often overlooked contributors to autoimmune disease.

In many cases, yes. We’ve helped patients reduce or eliminate triggers and achieve remission using natural, functional medicine strategies.

Not necessarily. We work alongside your current care team. Many patients reduce their need for medications over time—but always under supervision.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

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