What Does Depression Feel Like?

Introduction: Why Depression Needs a New Approach

Depression isn’t just a chemical imbalance—it’s a multifaceted condition that affects your mind, body, and spirit. At Patients Medical in New York City, we take a functional and integrative approach to treating depression. We don’t just mask symptoms with medication. Instead, we investigate root causes such as inflammation, nutritional deficiencies, gut imbalances, and chronic stress.

Our goal? To help you heal, naturally and completely—so you can feel like yourself again.

What Is Depression?

Depression is a mood disorder that causes persistent feelings of sadness, hopelessness, and loss of interest in daily activities. It affects how you think, feel, and function.

There are many types:

  • Major Depressive Disorder (MDD): Characterized by a deep, ongoing sadness and low energy that lasts at least two weeks.
  • Persistent Depressive Disorder (Dysthymia): A chronic, low-grade depression that lasts for two years or more.
  • Postpartum Depression: Affects women after childbirth due to hormonal shifts and emotional stress.
  • Seasonal Affective Disorder (SAD): Depression triggered by seasonal changes, typically in winter.
  • Bipolar Depression: Alternating episodes of depression and mania.

 

What Does Depression Feel Like?

Depression is more than just “feeling down.” Many patients describe it as:

Root Causes: Why Are You Depressed?

Functional medicine asks a deeper question: What’s driving your depression beneath the surface?

Here are some of the most common root causes we see:

  • Nutrient Deficiencies: Low levels of B12, magnesium, omega-3s, and vitamin D can impair mood regulation.
  • Hormonal Imbalances: Thyroid dysfunction, estrogen dominance, or adrenal fatigue can mimic or worsen depression.
  • Chronic Inflammation: Inflammation in the brain is now recognized as a major contributor to depression.
  • Gut Health Issues: Your gut makes over 90% of your serotonin. A disrupted microbiome or leaky gut affects mental health.
  • Toxin Overload: Mold, heavy metals, or chemical exposure can disrupt brain chemistry and energy.
  • Sleep Disturbances: Poor sleep increases risk for anxiety, depression, and cognitive decline.
  • Past Trauma or Unresolved Stress: Emotional trauma and chronic stress dysregulate the nervous system and HPA axis.
  • Mitochondrial Dysfunction: If your cells can’t make energy efficiently, your brain and mood suffer.

Diagnostic Testing We Use

To uncover the true cause of your depression, we offer advanced lab testing that goes beyond a typical psychiatric evaluation:

Inflammatory markers: CRP, homocysteine

Comprehensive thyroid panel (TSH, Free T3/T4, reverse T3)

Adrenal function (salivary or DUTCH cortisol)

Sex hormone levels (estrogen, progesterone, testosterone, DHEA)

Nutrient testing (B12, magnesium, folate, vitamin D, omega-3)

Gut microbiome analysis & leaky gut testing

Heavy metal and mold toxicity panels

Integrative Treatments for Depression

Nutritional Therapy

We design therapeutic diets to reduce inflammation and support brain chemistry:

  • Anti-inflammatory or Mediterranean plans
  • Gut-healing protocols
  • Gluten- and dairy-free diets if sensitivities are found
  • Targeted amino acid support for neurotransmitters

IV Nutrient Therapy

Targeted IV infusions support neurotransmitter production and mitochondrial health. Ingredients may include:

  • B-complex vitamins (especially B6, B12)
  • Magnesium
  • Vitamin C
  • Amino acids like tryptophan and tyrosine

 

Herbal & Nutraceutical Support

We prescribe evidence-based supplements for brain chemistry and mood balance:

  • SAM-e
  • St. John’s Wort (where appropriate)
  • 5-HTP
  • Rhodiola rosea
  • Omega-3 fish oil
  • Vitamin D3

 

Mind-Body Therapies

We offer holistic stress relief through:

  • Acupuncture
  • Guided meditation and mindfulness
  • Adaptogenic herbs (Ashwagandha, Holy Basil)
  • Biofeedback and neurofeedback (where indicated)

Hormone Balancing

We identify and treat imbalances in:

  • Thyroid hormones
  • Estrogen and progesterone
  • Cortisol and DHEA
  • Testosterone (for men and women)

Gut Restoration

Healing the gut helps regulate mood by improving neurotransmitter production and reducing inflammation. We use:

  • Probiotics and prebiotics
  • Gut-repairing nutrients like glutamine and zinc
  • Stool analysis-guided protocols

Case Study: James’ Journey Back to Himself

James, 46, came in with low motivation, fatigue, and emotional numbness. He had tried multiple antidepressants without success. Our testing revealed:

  • Low B12 and vitamin D
  • High homocysteine
  • Gut dysbiosis and candida
  • Blunted cortisol rhythm

His plan included:

  • B12 and vitamin D injections
  • Gut cleanse and probiotic protocol
  • Daily adaptogenic herbal support
  • Acupuncture and meditation sessions
  • Gradual tapering of SSRIs under supervision

In 3 months, James reported improved mood, sharper focus, and a renewed sense of purpose.

Testimonials

Frequently Asked Questions

If you consistently feel sad, numb, tired, or disconnected for two weeks or more, it may be depression. But the best way to know is to get evaluated.

Absolutely. Hormones, gut health, sleep, inflammation, and nutrient status all play major roles in mood.

Not necessarily. Many patients reduce or eliminate medications with our support—by addressing the underlying causes of their depression.

We use advanced diagnostic tools, including neurotransmitter panels, hormone testing, gut microbiome analysis, micronutrient testing, inflammatory markers, and genetic testing (like MTHFR).

Absolutely. Over 90% of serotonin is produced in the gut. An imbalanced gut microbiome or “leaky gut” can directly contribute to mood disorders and depressive symptoms.

Yes, when prescribed by a physician. We use clinically studied herbs and nutraceuticals like omega-3s, SAM-e, B-complex, and adaptogens, customized for your unique biochemistry.

Many patients begin noticing improvement in energy, mood, and sleep within a few weeks. However, deeper healing can take several months, depending on the complexity of underlying issues.

Yes, every plan is tailored to your lab results, symptoms, medical history, and goals. No two treatment protocols are alike.

Hormonal imbalances—especially thyroid, cortisol, estrogen, and testosterone—can significantly influence mood and brain function. We test and treat these to restore mental wellness.

We are an out-of-network provider but provide superbills to help with insurance reimbursement. Many lab tests may be partially covered depending on your plan.

Begin Your Journey with Patients Medical

Patients Medical specializes in gently helping the patient identify the root cause of their medical issues and then assist them to recover from their problems to help them move forward to good health.

Request your consultation today!

To schedule an in person on Tele-medicine appointment, please call our office at (212) 794-8800 or email us at info@PatientsMedical.com We look forward to hearing from you

Our medical center in New York City.

Patients Medical PC
1148 Fifth Avenue, Suite 1B New York, NY 10128

Make an Appointment